Abstarct: Background and Objective: The global epidemic of pre-diabetes and diabetes has led to complications with multiple disorders. Diabetic neuropathy is one of the common complications of type 2 diabetes, which is seen in 50% of patients. Diabetic neuropathy is the loss of sensory function that starts from the distal part of the lower limb and is associated with pain. The primary classification of diabetic neuropathy includes sensory-motor and autonomic neuropathy, where distal peripheral neuropathy is the most common type of neuropathy. This complication can appear in the form of movement disorders, postural hypotension, increased sweating, bladder dysfunction, and sexual disorders. Accurate blood sugar control and daily foot care are the main keys to preventing diabetic neuropathy problems. Therefore, the purpose of this research was to investigate the effect of exercise on nerve conduction factors and serum neurotrophin-3 (NT-3) on women with peripheral neuropathy of type 2 diabetes, whether it had an effect or not. Materials and Methods: The statistical population of this research was type 2 diabetic women with peripheral neuropathy (Michigan score above 7) referring to Diabetes Association and Imam Hossein Shahrood Hospital, of which 25 were randomly assigned to two exercise groups (n=13) and exercise group (n=13). n=12) with an average age of 40 to 65 years and a body mass index below 40 were divided. Exercises include 3 sessions per week for 12 weeks and each session is 90 minutes of resistance training with an intensity of 50-60% 1RM with 10-15 repetitions in 1-3 sets, with 30-60 second rest intervals between each exercise and 3-5 minutes. It was done between each round. ELISA method was used to measure NT-3. Also, the nerve conduction speed test was used to measure the conduction speed of the sensory and motor nerve and the action potential amplitude of the sensory and motor nerve. The data were analyzed using the Kolmogorov Smirnov test to check the normality of the data and to test the hypotheses, analysis of covariance was used at a significance level of p≤0.05 Results: The results in the training group compared to the control group indicated that 12 weeks of resistance training could increase NT-3 (P=0.001), nerve conduction velocity values (sural nerve conduction velocity (P=0.001), nerve conduction velocity peroneal (P=0.001), tibial nerve conduction velocity (P=0.001), sural nerve action potential amplitude (P=0.014), tibial nerve action potential amplitude (P=0.001); Also, there were significant changes in insulin factors (P=0.001), fat percentage (P=0.001), insulin resistance (P=0.002), weight (P=0.001) and BMI (P=0.001). Comparison between two groups has been reported, but it was not significant in peroneal nerve action potential amplitude (P≥0.05). Conclusion: In general, it seems that strength training can increase nerve conduction speed factors and decrease fasting blood sugar levels in women with diabetes type 2 neuropathy, which is probably realized with the focus of NT-3.